"ASIO settings
ASIO drivers: Choose the sound card driver which you would like to work with. The drivers
of all ASIO devices installed on the system will be listed here. Clicking on the "Settings"
button opens the settings dialog for the sound card driver. In the display field beside "ASIO
buffer" you'll see the buffer size and bit rate set for the driver. Additionally, Samplitude
shows you the relevant output and input latencies."
If you press 'Y' on your keyboard when the Samplitude program is running you should get a screen called 'System/Global Audio Properties'
The first selection in the audio driver type you can use: ASIO, MME, WDM(Multichannel)
Of course this might vary depending on the version of the Samplitude version you own, and you would need to know what sound card (hardware) you have, and what it is capable of processing. MME is most likely.
Walk you through no problem, John auvil has already answered some, but here is a video tutorial and you will find a lot of things even some thing you need later. In this General part please watch and you will know what to do. You better explore this website if you want to learn. Check thei tutorials.